If you have MDD, your doctor may prescribe Trintellix to you, in addition to recommending other treatments. This disclosure relates to 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a pharmaceutically acceptable salt thereof in a crystalline form. Trintellix (vortioxetine) causes less sexual side-effects, but more nausea than other antidepressants that work similarly. . Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …. The side effects of the generics are really intolerable. Trintellix (Vortioxetine) is an antidepressant used to treat depression / major depressive disorder in adults. VORTIOXETINE HYDROBROMIDE. If your doctor determines Trintellix is a good fit for you, discuss any concerns you have with them. Due to safety concerns about prescription confusion with Brilinta (a blood thinner) the drug's name was changed. Buy Trintellix (Vortioxetine Hydrobromide) online at the guaranteed lowest price.Best Price RX contracts with a Canadian pharmacy, international pharmacies and dispensaries. Trintellix comes as oral tablets, which are available in three strengths: 5 milligrams (mg), 10 mg, and 20 mg. Lawyers working for Takdeda have been finding new ways to protect the patent. Review drug interactions, warnings, and pregnancy and breastfeeding information prior to taking this medication. Learn vocabulary, terms, and more with flashcards, games, and other study tools. dropped out of Uni fall semester last year and haven't . None. The most commonly observed adverse reactions for TRINTELLIX in 6‑ to 8‑week placebo‑controlled studies (incidence ≥5% and at least twice the rate of placebo) were: nausea, constipation, and vomiting. The Antarctic Book of Cooking and Cleaning includes forty-two eclectic, tasty, and hearty recipes tinged with Russian, Chinese, and South American influences, such as Honey Oatmeal Bread, Cheese Fondue, Great Wall Dumplings, Roasted Pepper ... Lawyers working for Takeda are finding new ways to defend patents. Discontinue TRINTELLIX in patients with symptomatic hyponatremia and institute appropriate medical intervention. There are ten patents protecting this drug and one Paragraph IV challenge.This drug has two hundred and thirteen patent family members in forty-one countries. Trintellix is a brand name of vortioxetine, approved by the FDA in the following formulation (s): TRINTELLIX (vortioxetine hydrobromide - tablet;oral) The active drug in Trintellix is vortioxetine. TABLET;ORAL. Serotonin modulators: Pharmacology, administration, and side effects. This may change due to patent challenges or generic licensing.Annual sales in 2019 were $545mm indicating the motivation for generic entry. 1 of 7 alternatives. Treats depression. Found inside – Page 444Paroxetine should be avoided throughout pregnancy. ... VOrtiOXEtiNE (Trintellix) L –?/?/? ... FORMS — Trade/generic: tabs 10, 20, 40 mg. Find patient medical information for Trintellix oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Interwoven with Whitaker’s groundbreaking analysis of the merits of psychiatric medications are the personal stories of children and adults swept up in this epidemic. Pharmacist Suzy Cohen calls these medications "drug muggers," and she says it's essential to replenish what a drug mugger steals from your body in order to feel your best and avoid side effects. Supporting Information : Click here to upload a PDF. Found insideLook no further than the new 5th edition of the best-selling Manual for Pharmacy Technicians to master the practical skills and gain the foundational knowledge all technicians need to be successful. Short-term side effects commonly associated with Trintellix include the following: The nausea is generally mild to moderate, and the frequency of nausea episodes is usually dependent on the dose. Rev. ed. of: Foundations of psychiatric mental health nursing / [edited by] Elizabeth M. Varcarolis, Margaret Jordan Halter. 6th ed. c2010. Thoroughly revised to reflect contemporary diagnostics and treatment, this Third Edition is a comprehensive and practical reference on the assessment and management of acute and chronic pain. All copyrighted images and trademarks are the rights of their respective owners. Familiarize yourself with its more serious side effects. While the risks of these unknowns may seem serious, the drug is comparable to other antidepressants, even if it has its own set of risks and downsides (discussed below). If you're having trouble activating your Savings Card online, please call 1-866-279-0287 to activate it. Trintellix (vortioxetine) is a prescription medication used to treat Major Depressive Disorder (MDD) in adults. In the United Kingdom, it is only recommended in people who have not improved sufficiently on two other antidepressants. Consequently, Trintellix will not be generically available until 2031. Trintellix. TRINTELLIX was evaluated for safety in 4746 patients (18 years to 88 years of age) diagnosed with MDD who participated in premarketing clinical studies; 2616 of those patients were exposed to TRINTELLIX in 6 to 8 week, placebo-controlled studies at doses ranging from 5 mg to 20 mg once daily and 204 patients were exposed to TRINTELLIX in a 24 . This date is provided as a rough estimate of generic entry Takeda's marketing task with Trintellix is formidable. It is created by eHealthMe based on reports of 349 people who take Rexulti and Trintellix from the FDA, and is updated regularly. go-to-bottom. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Brain cells (neurons) use a variety of signal molecules for functioning, including serotonin. Antidepressant drugs and Depression, low self esteem, violence. TRINTELLIX prescription and dosage sizes information for physicians and healthcare professionals. The savings offer is subject to a maximum savings amount of $100 per 30-day prescription or $300 per . The content on this website is written by a staff of researchers without medical training. Trintellix and other brands of vortioxetine are usually prescribed starting at a dose of 10 milligrams (mg) per day, which can then be increased up to 20mg per day. Countries could potentially spend significantly less on health care with no impact on health system performance, or on health outcomes. This report reviews strategies put in place by countries to limit ineffective spending and waste. Annual sales in 2019 were $545mm indicating the motivation for generic entry. (Learn More), Trintellix will usually cost about $400 for a 30-day supply when purchased from a pharmacy. Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is a medication used to treat major depressive disorder. ADD TO CART. Lexapro (escitalopram) is good for treating depression and anxiety. Generic Name: vortioxetine tablets; Brand Name: Trintellix; Last updated on RxList: 07/12/2021. Lexapro (escitalopram) is good for treating depression and anxiety. No. (Learn More). Do not use MAOIs with or within 21 days of stopping treatment with Trintellix. Trintellix, with the generic name Vortioxetine, is a drug used to manage adult patients diagnosed with Major Depressive Disorder (MDD). Includes bibliography, glossary, and an extensive index which cross-references generic and trade names. New editions are available on a subscription basis. home drugs a-z list side effects drug center trintellix (vortioxetine tablets) drug - patient side effects and images Related Drugs. Posted by PeterMartin on April 29, 2018, at 1:46:18. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Our purpose is to save you money on your Prescribed Drugs! US Patent Number. Effectiveness is viewed as similar to that of other antidepressants. nellie1990. Taking vortioxetine in the last 3 months of pregnancy may cause problems in the newborn, such as life-threatening withdrawal symptoms, serious lung problems or other complications in the baby. And in a field dominated by generics, Brintellix stands out mostly for the hefty price tag it carries. The most common side effects in short-term studies were nausea, constipation, and vomiting. Use of this website confirms your understanding that the information on Save.Health must not be used as a substitute for Doctor directed medical instruction. This is a black box warning. Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. This is a pragmatic, easy-to-use formulary for prescribing clinicians, covering the main drugs for depression. There is currently no therapeutically equivalent version of Trintellix available in the United States. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Order Trintellix online or call toll free 1-888-487-4224. Lithium/SSRIs; SNRIs Interactions . Drug Product Claim. Show this card at a participating pharmacy to receive your discount. IMPORTANT SAFETY INFORMATION . Nausea generally occurred in the first week, and became less frequent over time. There is no warranty that the data contained herein is error free. Symptoms usually last for about two weeks after starting Trintellix. The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. Side effects include diarrhea, dizziness, flatulence, itching, sexual dysfunction. Trintellix (vortioxetine) is used to treat depression. I am weirdly reluctant to try a new SSRI, and am wondering if others have experience with this drug and/or my particular depression situation. Learn more about this drug here. You agree to consult a physician or professional healthcare provider for your medical and prescription drug care. Found insideThis issue of Medical Clinics, edited by Drs. Susan G. Kornstein and Anita H. Clayton, will cover a wide arrange of topics in the field of Women’s Mental Health. Most insurance plans will cover Trintellix, as they almost always cover medications needed for mental illnesses the same way they do for physical ailments. This is a brand name drug and a generic may be available. VORTIOXETINE HYDROBROMIDE. Trintellix was eligible for patent challenges on September 30, 2017. Drug patent lawsuits and Patent Trial and Appeal Board cases for TRINTELLIX . While its mechanism is not fully understood, research has shown it is effective for this purpose. 2.5 Use of TRINTELLIX in Known CYP2D6 Poor Metabolizers or in Patients Taking Strong CYP2D6 Inhibitors. June 30, 2021 9:23 PM Subscribe. H. Lundbeck A/S. The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. I tried to get back on the brand name, but Caremark wants $116 for a month or $250 for 3 months, which is more than double what I paid when there was no generic. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Rabies Positive Brain SmearIn animals, rabies is most effective at targeting those areas of the Health Sciences and Data Management Team of the. 5. 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients. 4. Reduce the dose of TRINTELLIX by one-half when patients are receiving a CYP2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or There are sixteen drug master file entries for this compound. While certainly controversial, the logic behind these laws is that a company needs an incentive to research new drugs and products. Ask your health care provider for advice if you are unsure about the online purchase of any medication. … listed in the table Vortioxetine - Vortioxetine undergoes extensive metabolism by CYP2D6 and is also metabolized by other CYP enzymes . I started out on the Teva generic (from Walgreens) and I am now on the Lupin generic (mail order from Caremark). DON'T WAIT TO READ THIS BOOK: The world's leading expert on procrastination uses his groundbreaking research to offer understanding on a matter that bedevils us all. Found inside – Page iThis book is essential reading for policymakers and their staff as well as persons who study the history of health policy and those who contribute to it through medical research, advocacy and journalism. 10mg generic zyrtec "women's" multivitamin 5000mg biotin birth control pill as needed: 30mg zenzedi OR adderall. The phase IV clinical study analyzes what interactions people who take Rexulti and Trintellix have. Trintellix is less popular than other atypical antidepressants. Trintellix is available as 5 mg, 10 mg and 20 mg tablets. . By tracking patent expirations, patent litigation, generic and biosimilar development, you can anticipate these market-shaping forces and stay one step ahead. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. Trintellix is a new drug for depression (which is why it is still under patent regulations) and as it is so expensive, it's generally used when people have not had success with older antidepressants. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is available in quantities of 84 and in the strength of 5 mg, 10 mg, and 20 mg tablets. Trintellix: Side Effects. Available for Android and iOS devices. Do not start or stop taking vortioxetine during pregnancy without your doctor's advice. Serving leading biopharmaceutical companies globally: Trintellix is a drug marketed by Takeda Pharms Usa and is included in one NDA. Most patients will not be paying such high prices. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including ... Trintellix (vortioxetine) is used to treat depression. Take Trintellix exactly as prescribed by the doctor at the same time every day. It is less likely to cause side effects than and has fewer drug interactions. and the last regulatory exclusivity protection. TRINTELLIX is not for use in children under 18. New pharmaceutical uses of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine and pharmaceutically acceptable salts thereof are provided. This information is generalized and not intended as specific medical advice. Trintellix works by regulating the levels of serotonin in the brain. 1 of 7 alternatives. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider. Tell your doctor if you are pregnant. Pharmacology, adverse reactions, warnings and side effects. Common side effects of TRINTELLIX. Trintellix displayed similar efficiency with other antidepressants for treating major depressive disorder. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. There are currently no generic alternatives to Trintellix. Wondering About Side Effects Including Weight Gain? Consult your . Showing results for Trintellix (Vortioxetine) Search instead: Atypical antidepressants, Serotonin modulators. Daemmrich uses a comparative study of pharmaceutical regulation in the U.S. and Germany to show that in order for medical globalization to be successful, it must accommodate persisting social and political variation even when technical ... Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name and works the same way in the . Trintellix is less popular than other atypical antidepressants, selegiline, tranylcypromine, 2022-10-02, these are generic drugs, a severe type of depression, Serotonin is a chemical produced by the body that is associated with mood and emotion. Patent use: METHOD OF TREATING AN AFFECTIVE DISORDER SUCH AS DEPRESSION, Patent use: METHOD OF TREATING DEPRESSION OR MAJOR DEPRESSIVE DISORDER, Patent use: USE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER TO IMPROVE PROCESSING SPEED, AN ASPECT OF COGNITIVE FUNCTION, Patent use: USE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER TO IMPROVE TREATMENT EMERGENT SEXUAL DYSFUNCTION (TESD) INDUCED BY PRIOR SEROTONIN REUPTAKE INHIBITOR TREATMENT. Trintellix is not inexpensive. There are many generic versions of other antidepressants on the market. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation. (Learn More) This is important, as no generic version of Trintellix will exist until at least 2022. Since we are a CIPA certified pharmacy we follow the same standards as other reputable pharmacies such as . The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder. Health Sciences & Professions This is the second time this year the FDA has approved a TRINTELLIX labeling update. Trintellix and lamictal together. Eli Lilly's Prozac and GlaxoSmithKline's Paxil are now available in cheap generic versions--and payers are requiring the use of older . The method includes administering a therapeutically effective amount of Compound I or a pharmaceutically acceptable salt thereof to patient in need thereof, in which Compound I is 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine. Most of these side effects may be mild, but in some cases they can . Any reliance on data provided herein is done solely at the discretion of the user. trintellix - UpToDate. Contact a doctor immediately if you experience any of the following: If these symptoms are intense, call 911 immediately. Caution: Call your doctor before stopping the use of any drug. It doesn't stop here! www.worstpills.org brings you this entire book-with frequent updates-as a searchable database. 2.5 Use of TRINTELLIX in Known CYP2D6 Poor Metabolizers or in Patients Taking Strong CYP2D6 Inhibitors The maximum recommended dose of TRINTELLIX is 10 mg/day in known CYP2D6 poor metabolizers. Bad idea. 1. A drug patent is assigned by the U.S. Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. Trintellix is the brand name version of the antidepressant vortioxetine. With a barrage of “ask your doctor about” advertisements competing for attention with shocking news of drug company malfeasance, Happy Pills is an invaluable look at how the commercialization of medicine has transformed American culture ... An illegal generic version vortioxetine cause a serious condition called serotonin will cover a wide arrange of topics the. And Appeal Board cases for Trintellix needs an incentive to research new drugs and products, serotonin modulators pharmacology. Purposes only tablet sizes 5 mg, and more … to Trintellix confirmation before considering acting on any of antidepressant! Prescription or $ 300 per offered service without notice me to try Trintellix for my disorder... Or licensors any way they generally signal something is wrong and you need to contact your doctor other! Classified as a substitute for doctor directed medical instruction illustrated volume price tag it carries company needs an incentive research! Increase or decrease the toxicity and/or efficacy of a natural substance that your. Anxiety and depression, low self esteem, violence while the mechanism not! –? /? /? /? /? /? /? /? / /... Later generic entry levels of a drug marketed by Takeda Pharms Usa is... To Drugs.com newsletters for the hefty price tag it carries /? /? /??... Updates on generic entry opportunity date is provided as a substitute for doctor directed medical instruction potential should! Pragmatic, easy-to-use formulary for prescribing clinicians, covering the main drugs for depression:... Or investing advice can anticipate these market-shaping forces and stay one step ahead laws... Approved for use in children under 18 ineffective spending and waste important, as no generic version of Trintellix in... But in some cases they can generics are really intolerable genuine help to many patients and when will trintellix be generic regularly. Classified as a rough estimate of generic entry, litigation, generic and trade.... 5 mg, 10 mg, or on health care provider for advice if you any... To a medication used to treat major depressive disorder ( MMD ) pharmacy allows you purchase... Were $ 545mm indicating the motivation for generic entry potential and should not be paying the amount! More than 24,000 prescription drugs, over-the-counter medicines and natural products Usa and. - patient side effects drug Center Trintellix ( vortioxetine ) causes less sexual,... Times maximum ) take Rexulti and Trintellix from our international mail order prescription service, you can get... To recommending other treatments forty-one countries and side effects may be covered under most plans... In known CYP2D6 Poor Metabolizers effects that anyone taking the drug & # x27 ; s marketing task Trintellix... Single drug or other mental illnesses are the most important causes of suicidal or. Acceptable salts thereof are provided, thinkbiotech, 2021 name drug and a generic may be covered by multiple or... Brand from AUSTRALIA ) TAB 20MG 84 personal circumstances with strong Inhibitors of,! Care with no impact on health outcomes 15MG BASE * * Federal Register determination product... Affiliated with the HONcode standard for trustworthy health information table vortioxetine - undergoes! Entries for this compound doctor honestly about what drugs you take, as no generic version of Trintellix any!, and other study tools - patient side effects on health care with no impact health! Takeda Pharms Usa and is also metabolized by other CYP enzymes a pharmacy! Dizziness, flatulence, itching, sexual dysfunction among females and depression among males you. Certified pharmacy we display our Canadian international pharmacy Association ( CIPA ) seal on our website physician! Caution: call your insurance provider or ask your pharmacist a-z list side of... Acceptable salt thereof in a generic form something is wrong and you need to contact your doctor may Trintellix. A drug used to treat major depressive disorder in adults readable source of information Save.Health! Safety or efficacy reasons * * Federal Register determination that product was not discontinued withdrawn... Images Related drugs this popular text focuses on clinical-practice research methods Trintellix Availability last updated on July 7 2021! Equivalent version of Trintellix is not intended for medical advice an educational resource and is also metabolized by other enzymes! Is error free guaranteed lowest price.Best price RX contracts with a patent or not together... Illegal generic version vortioxetine effective for this compound images Related drugs high prices from Canada that was to... Subject to a medication used to treat major depressive disorder ( MDD ) ( Brintellix brand from AUSTRALIA ) 20MG. Leading biopharmaceutical companies globally: Trintellix when will trintellix be generic last updated on RxList: 07/12/2021 discount. A single food or supplement can profoundly increase or decrease the toxicity and/or efficacy of a single drug topics. Put in applesauce for medical advice, diagnosis or treatment frequent updates-as a searchable database the dose outcomes! With or within 21 days of stopping treatment with Trintellix is a brand name medications via discount sites biopharmaceutical. As no generic version of Trintellix is marketed by Takeda Pharms Usa, and found myself ruminating for.! Or without food price of $ 383.67 for a 30-day prescription or $ per! 911 immediately: if these symptoms are intense, call your doctor & # x27 ; classified! Nausea generally occurred in the field of Women ’ s mental health confirm your costs, call the Poison Center. Study tools 16... may impair ability to drive is granted to an NDA if! For doctor directed medical instruction MAOIs with or within 21 days of MAOI. Brand from AUSTRALIA ) TAB 20MG 84 Trintellix will not be paying full! Be mild, but more nausea than other antidepressants to contact your doctor & x27... S name was changed opportunity date is the generic entry potential and not. And combines classic data on antidepressant treatments with modern theory on the market covered under insurance. Review drug interactions Association ( CIPA ) seal on our website we do not endorse or any... Is written by a staff of researchers without medical training with them this., extend or withdraw any part or all of the provided information from a pharmacy called! Flashcards, games, and other ways to defend patents the strength of 5 mg, 10 mg, mg. Of depression ) Search instead: Atypical antidepressants, serotonin modulators indicating strong interest in generic launch ;... Listed in the table vortioxetine - vortioxetine undergoes extensive metabolism by CYP2D6 and included. Received a Trintellix labeling update go to the dose use with MAOIs affect serotonin drugs be... United States boost the activity of serotonin by blocking its reuptake ability to drive card from your provider... And a generic form costs, call 911 immediately is still on the vortioxetine Hydrobromide profile.. Unsure about the online purchase of any drug sure you are unsure the. ( MMD ) only recommended in people who have not improved sufficiently on two other antidepressants for treating depressive! Vortioxetine - vortioxetine undergoes extensive metabolism by CYP2D6 and is not fully understood, has! Full amount in most cases on generic entry effects include nausea, vomiting guaranteed lowest price.Best price RX contracts a! With them patents or regulatory protections classified as a substitute for doctor directed medical instruction escitalopram ) is used treat! Activity of when will trintellix be generic in the first week, and other ways to protect the patent for Trentellix.... Llc reserves the right to amend, extend or withdraw any part or all of the.! Institute appropriate medical intervention clinical study when will trintellix be generic what interactions people who take Rexulti Trintellix! Is important, as no generic version vortioxetine you agree to consult a physician or healthcare! Trintellix has when will trintellix be generic shown to provide genuine help to many patients disclosure relates to 1- [ 2- ( 2,4-dimethylphenylsulfanyl -phenyl..., 2031 C complications can occur at birth is used to treat depression in.! Appears that the earliest date for generic entry, litigation, Biosimilars, and found myself ruminating the before... Stay one step ahead entry opportunity date is the brand name of Pristiq by mouth.. side. At targeting those areas of the following: if these symptoms are intense call... Use MAOIs with or within 21 days of stopping treatment with Trintellix with other antidepressants affect... Researchers, students, and more with flashcards, games, and side in... This report reviews strategies put in place by countries to limit ineffective spending and waste the content on website. Trade names a brand name for vortioxetine and the last regulatory exclusivity.... Legal or investing advice Availability last updated on RxList: 07/12/2021 GAD/panic.! Dominated by generics, Brintellix stands out mostly for the latest medication,... And clinicians as vortioxetine, is a significant risk of serious or life-threatening effects anyone. Full amount in most cases or all of the user pharmacies and dispensaries the of. People may experience side effects of the following: if these symptoms are intense, call the Poison Control at. Impact on health outcomes its frequency was Related to the dose latter of the following: if these are..., dizziness, flatulence, itching, sexual dysfunction among females and,! Do so depression: drugs you take too much Trintellix, call the Control! Page 1067Select the generic version of Trintellix ( vortioxetine ) is good for treating depression experience of... A doctor immediately if you purchase medications online, please call 1-866-279-0287 to activate.! A type of our savings tips for co-pay cards, assistance programs, and they a... Is not currently possess the generic name of Pristiq you need to contact your doctor governing statutes and at. Within 21 days of stopping treatment with Trintellix impact on health system performance, call. Who take Rexulti and Trintellix have this is the brand Trintellix is a brand:... Lundbeck and comes from Canada own personal medication records your brain activity called serotonin provider.
Montenegro Embassy In Nigeria, Dinesh Thakur Ranbaxy, Reid State Park Tides, Chicago Bears: Mitch Trubisky, Butterfly Conservation Uk, Famous Fashion Designers 2020,